Biomaterial Coating for Recruiting Endothelial Progenitor Cells
نویسندگان
چکیده
Introduction We propose to investigate whether a synthetic vascular graft biomaterial coating can be used for promoting homing, attachment and differentiation of circulating endothelial progenitor cells (EPCs). The vascular graft is based on a modified ePTFE graft using a coating of the copolymer, poly(1,8-octanediol-co-citrate) (POC) to allow for electrostatic binding of stromal cell derived factor-1α (SDF-1). SDF-1 is a potent chemotactic factor for EPCs [1, 2]. We aim to modify ePTFE with POC and SDF-1 such that it has the potential to recruit and differentiate circulating EPCs in vivo.
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